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Neonatology

Poster Session 1

(134) Late preterm antenatal corticosteroids and neonatal hypoglycemia: a cohort study

Tuesday, February 13, 2024
10:30 AM – 12:00 PM  
Location: Prince George's Exhibit Hall CDE, Lower Atrium Level

    Primary & Presenting Author(s)

  • Mauricio Carrillo, MD (he/him/his)

    Clinical Professor in Materno fetal medicine
    Fundación Santa Fé de Bogotá, Department of Gynecology and Obstetrics
    Bogota, Distrito Capital de Bogota, Colombia

    • Coauthor(s)

  • FC

    Fernando Castañeda, MD

    Universidad El Bosque, Gynecology and Obstetrics
    Bogota, Distrito Capital de Bogota, Colombia

  • NR

    Nicolas Rodriguez, MD, MSc

    Fundación Santa Fé de Bogotá, Department of Gynecology and Obstetrics
    Bogota, Distrito Capital de Bogota, Colombia

  • IM

    Ivana Moyano, N/A

    Universidad del Rosario, School of Medicine
    Bogota, Distrito Capital de Bogota, Colombia

Objective:

To determine associations between antenatal corticosteroid (AC) administration in late preterm fetuses with presence of neonatal hypoglycemia (NH)

Study Design:

Retrospective cohort study in pregnant women with late preterm deliveries at University Hospital Fundación Santa Fe de Bogotá 2019–2022. The exposure of interest was AC administration of betamethasone during pregnancy between 34 0/7 and 36 6/7 weeks in singleton and twin gestations. The primary outcome was NH. Descriptive analysis based on averages and percentages, and multivariable logistic regression were used to estimate the association between AC exposure and NH. We stratified the study by singleton and twin gestations, corticosteroids dose, maternal outcomes and neonatal outcomes. Statistical analysis was performed using Odds Ratio(OR), confidence intervals and p values.

Results:

6017 total deliveries, 528 (8.7%) late preterm, 378 (71,5%) singleton and 150 (28.5%) twin pregnancies. 330 mothers received AC, 260 (78.8%) were singleton and 70 (21.3%) were twin pregnancies. There were no statistical differences between all late preterm fetuses who received AC and those who did not received and developed NH (OR=1.09, 95% CI [0.71-1.67], p=0.699), no significant statistically relationship between AC and NH when we adjusted by: singleton (OR= 0.78, 95%CI[0.43-1.43], p=0.428), or twins (OR=1.12, 95%CI[0.56-2.25], p=0.742). There were no association when we adjusted by number of corticosteroids dose, full course, or partial course (OR=0.96, 95%CI[0.62-1.48], p=0.860). There were no significant statistically relationship between AC and NH adjusted by maternal and neonatal clinical conditions such as preeclampsia, premature rupture of membranes, gestational diabetes, fetal growth restriction, olygoamnios, neonatal sepsis, polycythemia, jaundice, and respiratory distress syndrome.

Conclusion:

Exposure to AC in singletons and twins during late preterm period is not associated with increased odds of hypoglycemia. In our population several maternal and neonatal clinical conditions do not change the significant statistical relationship between AC and NH.