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Q&A

Fetus

Poster Session 4

(1184) The association between being born small for gestational age and childhood inflammatory bowel disease

Wednesday, February 14, 2024
1:00 PM – 2:30 PM  
Location: Prince George's Exhibit Hall CDE, Lower Atrium Level

    Primary & Presenting Author(s)

  • Orit Wissotzky Broder, MD, MHA

    OBGYN RESIDENT
    Soroka Medical Center
    Kibutz Lahav, HaDarom, Israel

    • Coauthor(s)

  • Gali Pariente, MD

    Acting director of Fetal Maternal Unit B Division of Obstetrics and Gynecology
    Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel
    Klahim, HaDarom, Israel

  • Tamar Wainstock, PhD (she/her/hers)

    Ben Gurion University
    Beer-Sheva, HaDarom, Israel

  • Eyal Sheiner, MD, PhD

    Head of department of Obstetrics and Gynecology B, Soroka University Medical Center
    Soroka University Medical Center
    Beer-Sheva, HaDarom, Israel

Objective:

The pathogenesis of inflammatory bowel disease (IBD) is considered multifactorial. Genetic changes, environmental factors and mostly dysregulated immunity, all play a role in the pathogenesis of IBD. Being born small for gestational age (SGA) is known to be related to immunologic aberrations and endothelial dysfunction leading to abnormal placentation. As both IBD and being born SGA share common pathophysiologic features, we sought to investigate the association between being born SGA and childhood IBD.

Study Design: A population-based cohort study was conducted. Deliveries occurred between the years 1991-2021 in a tertiary medical center, infants followed up to the age of 18 years. Data for the diagnosis of IBD was extracted from community-based clinics and hospitalization records. Kaplan-Meier survival curve was used to compare the cumulative incidence of childhood IBD of SGA and non-SGA infants. A Cox proportional hazard model was used to control for confounders.

Results:

During the study period, 356,356 singleton deliveries occurred, of which 16,210 (4.5%) infants were born SGA. Being born SGA, was not associated with childhood IBD (0.2% vs. 0.1%, p=0.118, Table). The Cox proportional hazard model adjusted for maternal and gestational age demonstrated that being born SGA was not independently associated with childhood IBD (Adjusted HR 0.94, 95% CI 0.63-1.39, p=0.761, Table).

Conclusion: Being born SGA is not a risk factor for childhood IBD.