Icon Legend

This session is not in your schedule.

This session is in your schedule. Click again to remove it.

Presentation Icons

Additional registration fee required

Faculty have requested this content not be shared on social media

CME Credit Offered

Poster Icons

Foundation Awardee

No Social Media

Back

Q&A

Epidemiology

Poster Session 1

(271) The effects of pregnancy conceived after fertility treatment on perinatal outcomes; a sibling analysis.

Tuesday, February 13, 2024

10:30 AM – 12:00 PM

Location: Prince George's Exhibit Hall CDE, Lower Atrium Level

Primary Author(s)

Oren Malka

Joyce and Irving Goldman Medical School Ben Gurion University
Beer-Sheva, HaDarom, Israel

Coauthor(s)

Tamar Wainstock, PhD (she/her/hers)

Ben Gurion University
Beer-Sheva, HaDarom, Israel
Eyal Sheiner, MD, PhD

Head of department of Obstetrics and Gynecology B, Soroka University Medical Center
Soroka University Medical Center
Beer-Sheva, HaDarom, Israel
AZ

Atif Zeadna, MD

Soroka University Medical Center
Beer-Sheva, HaDarom, Israel

Presenting Author(s)

Gali Pariente, MD

Acting director of Fetal Maternal Unit B Division of Obstetrics and Gynecology
Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Klahim, HaDarom, Israel

Objective: Recent studies have reported an association between fertility treatments and adverse perinatal outcomes. However, the precise contribution of maternal factors versus the fertility treatments per-se to these adverse outcomes remains unclear. This study used a unique sibling analysis method to investigate perinatal outcomes between pregnancies conceived using fertility treatment and spontaneously conceived pregnancies. Using sibling analysis as a study approach allows thorough examination of the association between conception mode and adverse perinatal outcomes while omitting unmeasured potential confounders.

Study Design: In a population-based retrospective cohort study, perinatal outcomes of pregnancies conceived following fertility treatment were compared to spontaneously conceived pregnancies of the same women. The study population included all mothers who had at least two deliveries between the years 1991-2021 at a tertiary medical center, with one pregnancy conceived following fertility treatments and another spontaneously conceived pregnancy. The comparison was done using maternal clusters analysis. Generalized linear models were used to control for confounders.

Results: During the study period 12,755 deliveries were included, of which 7,711 (60.5%) were conceived following fertility treatments. Using generalized linear models, controlling for maternal age, pregnancies conceived following fertility treatments were independently associated with adverse perinatal outcomes including hypertensive disorders (9.9% vs. 5.8%, p< 0.001), gestational diabetes mellitus (12.7% vs. 7.1%, p< 0.001), placenta previa (1.4% vs. 0.5%, p< 0.001), preterm delivery (11.7% vs. 7.5%, p< 0.001), cesarean delivery (34.1% vs. 21.1%, p< 0.001) and small for gestational age (5.3% vs. 3.3%, p< 0.001, Table 1).

Conclusion:

Using maternal clusters analysis, pregnancies conceived following fertility treatments were found to be independently associated with higher risk for adverse perinatal outcomes.