Skip to main content
SMFM 2024 Pregnancy Meeting Main banner
Final Program


Icon Legend
This session is not in your schedule.
This session is in your schedule. Click again to remove it.
Presentation Icons
Additional registration fee required
Additional registration fee required
Faculty have requested this content not be shared on social media
Faculty have requested this content not be shared on social media
CME Credit Offered
CME Credit Offered
Poster Icons
Foundation Awardee
Foundation Awardee
No Social Media
No Social Media
Back
Q&A

Medical/Surgical/Diseases/Complications

Poster Session 4

(1142) Long- term infectious morbidity of offspring born to women with psoriasis

Wednesday, February 14, 2024
1:00 PM – 2:30 PM  
Location: Prince George's Exhibit Hall CDE, Lower Atrium Level

    Primary & Presenting Author(s)

  • Moran Shahar, MD

    Soroka
    Carmit, HaDarom, Israel

    • Coauthor(s)

  • Gil Gutvirtz, MD

    Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
    Metar, HaDarom, Israel

  • Tamar Wainstock, PhD (she/her/hers)

    Ben Gurion University
    Beer-Sheva, HaDarom, Israel

  • Gali Pariente, MD

    Acting director of Fetal Maternal Unit B Division of Obstetrics and Gynecology
    Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel
    Klahim, HaDarom, Israel

  • Eyal Sheiner, MD, PhD

    Head of department of Obstetrics and Gynecology B, Soroka University Medical Center
    Soroka University Medical Center
    Beer-Sheva, HaDarom, Israel

Objective: Psoriasis is a common skin disease with prevalence of 1.5-2.2% in the adult population. About half of psoriasis patient are women, presenting usually before the age of 40. Limited data exists regarding long-term morbidity of the offspring in women with psoriasis. The objective of this study was to assess long-term infectious morbidity of the offspring born to women with psoriasis.

Study Design: In a population-based cohort study, long- term infectious hospitalizations of the offspring were compared between singletons born to mothers with and without psoriasis. Deliveries occurred between the years 1991-2021 in a regional tertiary medical center. Infectious related morbidity up to the age of 18 years was assessed according to a predefined set of ICD-9 codes associated with offspring hospitalizations. A Kaplan-Meier survival curve was used to assess cumulative incidence of infectious related morbidity of the offspring and a Cox proportional hazards model was performed to control for confounders.

Results: During the study period 356,356 deliveries met the inclusion criteria, 240 (0.07%) occurred in women with psoriasis. Rates of long- term infectious hospitalizations of the offspring were comparable between the groups (30.4% vs 24.1% for offspring to mothers with and without psoriasis, respectively, p=0.129). However, the cumulative incidence of long- term infectious morbidity was higher among offspring born to women with psoriasis (Kaplan-Meier Log -rank = 0.050, Figure). In a Cox proportional hazards model, controlling for birth-weight, being born to a woman with psoriasis was independently associated with long term infectious morbidity of the offspring (adjust HR = 1.2, 95% CI 1.01-1.58; p=0.049).

Conclusion: Being born to a mother with psoriasis is an independent risk factor for long-term infectious morbidity of the offspring.