Skip to main content
SMFM 2024 Pregnancy Meeting Main banner
Final Program


Icon Legend
This session is not in your schedule.
This session is in your schedule. Click again to remove it.
Presentation Icons
Additional registration fee required
Additional registration fee required
Faculty have requested this content not be shared on social media
Faculty have requested this content not be shared on social media
CME Credit Offered
CME Credit Offered
Poster Icons
Foundation Awardee
Foundation Awardee
No Social Media
No Social Media
Back
Q&A

Prematurity

Poster Session 1

(154) Antenatal late preterm steroids in twin gestations

Tuesday, February 13, 2024
10:30 AM – 12:00 PM  
Location: Prince George's Exhibit Hall CDE, Lower Atrium Level
Objective: The administration of antenatal steroids in the late preterm period (34+0 to 36+6 weeks gestation) to improve neonatal outcomes is now common. Our objective was to evaluate maternal and neonatal outcomes in twin gestations who received antenatal steroids in the late preterm period.

Study Design: We conducted a retrospective cohort study of twin gestations delivered between 34+0 and 36+6 weeks gestation within our health system from 2020-2021. Subjects were excluded if they received steroids before 34 weeks gestation or had Type 2 diabetes. Our primary outcome was a composite of respiratory treatment for either or both twins (continuous positive airway pressure or high-flow nasal cannula for at least 2 hours, supplemental oxygen with a fraction of inspired oxygen of 30% for at least 4 hours, extracorporeal membrane oxygenation, mechanical ventilation, or death). Secondary outcomes included other adverse neonatal outcomes and maternal infection and length of stay. Groups were compared via t-tests, chi-squared analysis, Fisher’s exact test, and linear and logistic regression.

Results: 205 patients delivered in the late preterm period without administration of steroids before 34 weeks gestation. Of these, 71 (34.63%) received steroids in the late preterm period. Those receiving steroids were older (32.0 vs. 30.6 years, p < 0.05), more likely to have a hypertensive disorder of pregnancy (43.7% vs. 29.9%, p < 0.05), and delivered earlier (35.6 vs. 35.9 weeks, p < 0.05). Between the two groups, there was no difference in the primary composite outcome of respiratory support requirement, neonatal intensive care unit admission, neonatal hypoglycemia, or other neonatal outcomes. Those who received steroids had longer maternal postpartum stays (3.2 vs. 2.7 days, p < 0.05), including when controlling for other factors.

Conclusion: There was no difference in neonatal outcomes with administration of late preterm steroids to multiple gestations. Maternal postpartum length of stay was longer, suggesting patients receiving antenatal steroids may have been more unwell at baseline.