(210) Association of maternal serum insulin-like growth factor-1 and fetal fractional thigh volume

Insulin-like growth factor-1 (IGF-1) is one of the growth factors that promote protein and carbohydrate metabolism, and consequently affects birth weight. Fetal fractional thigh volume has been proposed as a useful parameter for predicting birth weight and quantifying fetal soft tissue development. However, the association between maternal serum IGF-1 and fetal fractional thigh volume remains unclear. This study aimed to investigate the association of maternal serum insulin-like growth factor-1 and fetal fractional thigh volume.

Study Design:

A prospective study was conducted in a cohort of 24 singleton pregnancies. Maternal blood sample was obtained at 24 weeks’ gestation, and fetal ultrasonography was performed at 24-, 30-, and 36-weeks’ gestation. Fractional thigh volume was assessed as cylindrical limb volumes based on 50% of the fetal total diaphysis length using 3D ultrasonography. The association between maternal serum IGF-1 and fetal fractional thigh volume was examined using Pearson product moment correlations.

Results:

Maternal serum IGF-1 at 24 weeks was 140.0±5.7 ng/ml (mean±S.E.). Maternal IGF-1 was not associated with fetal fractional thigh volume at 24 weeks (r = 0.016, p = 0.930) and 30 weeks (r = 0.229, p = 0.216). Maternal IGF-1 significantly correlated with fetal fractional thigh volume at 36 weeks (r = 0.475, p = 0.019).

Conclusion:

Maternal serum IGF-1 at 24 weeks significantly correlated with fetal fractional thigh volume in late gestation. Maternal serum IGF-1 in mid-gestation could be a marker for predicting fetal growth in late gestation.