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Diabetes

Poster Session 2

(424) Association between resilience and depression in patients with gestational diabetes

Tuesday, February 13, 2024
3:30 PM – 5:00 PM  
Location: Prince George's Exhibit Hall CDE, Lower Atrium Level
Objective: Research has shown higher rates of postpartum depression among p</span>atients diagnosed with gestational diabetes (GDM). Resilience could be a protective factor against depression and improve maternal adjustment to GDM diagnosis. Our objective was to examine the association between resilience and depression in patients with GDM.

Study Design: Secondary analysis of the Nulliparous Pregnancy Outcomes study: Monitoring Mothers-to-be (nuMoM2b) dataset. Primary exposure was resilience, measured by Connor-Davidson Resilience Scale early in pregnancy and analyzed by tertiles, with the first tertile including patients with the lowest resilience score, and the third tertile with the highest resilience. The primary outcome was depression measured later in pregnancy, defined as Edinburgh Postnatal Depression (EDPS) score ≥ 10. Logistic regression was done to examine the association between maternal resilience and depression in GDM pregnancies, adjusting for marital status, insurance, maternal education, age, and BMI.

Results: Of 340 participants included, 34.4% had resilience score in the lowest tertile, 32.9% had resilience in the second tertile, and 32.6% in the third tertile. EDPS score was significantly higher in the first and second tertile compared to the third tertile (7.6.2 ± 4.2, 5.6 ± 3.2, and 3.9 ± 3.6 respectively, p< 0.001). A total of 56 (18.2%) patients in this cohort had EDPS ≥ 10, and the rates were higher with lower resilience tertile (31.6% in the 1st tertile, 8.9% in the 2nd tertile, and 8.1% in the 3rd tertile, p< 0.001). In unadjusted analysis, participants with higher resilience had lower odds of EDPS ≥ 10 (Table). In a multivariable analysis, higher resilience tertile remained to be independently associated with lower depression/EDPS ≥ 10 (aOR 0.22, 95% CI 0.10-0.47 for tertile 2, and aOR 0.20, 95% CI 0.09-0.46 for tertile 3), compared to the lowest tertile of resilience score (Table).

Conclusion: In pregnancies complicated by GDM, higher maternal resilience at the beginning of pregnancy was associated with lower odds of depression.