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Diabetes

Poster Session 3

(875) Nocturnal Time Above Range with Continuous Glucose Monitoring and Large for Gestational Age Newborn

Wednesday, February 14, 2024

8:30 AM – 10:00 AM

Location: Prince George's Exhibit Hall CDE, Lower Atrium Level

Primary & Presenting Author(s)

Sarah Nazeer, MD (she/her/hers)

Maternal-Fetal Medicine Fellow
McGovern Medical School at UTHealth Houston
Houston, TX, United States

Coauthor(s)

RS

Rafael Santos, PhD

McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth)
Houston, TX, United States
CP

Claudia Pedroza, PhD

McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth)
Houston, TX, United States
SB

Sean C. Blackwell, MD

Professor
Children's Memorial Hermann Hospital
Houston, TX, United States
Baha M. Sibai, MD

Professor
Hermann Memorial Hospital
Houston, TX, United States
Michal Fishel Bartal, MD (she/her/hers)

Maternal Fetal Medicine Faculty
McGovern Medical School at UTHealth Houston, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Houston, TX, United States

Objective: Recent data suggests a correlation between nighttime maternal blood sugars and neonatal birthweight. We aimed to examine the association between nighttime continuous glucose monitor (CGM) metrics and neonatal birthweight among individuals using CGM during gestational diabetes (GDM) screening.

Study Design: This was a secondary analysis of the prospective study (06/2020 to 01/2022) of individuals who underwent 2-step GDM screening at ≤ 30 weeks. Participants wore a blinded CGM (Dexcom G6 Pro) for ten days during the 1-hour glucose challenge test (GCT). We evaluated nocturnal TAR defined as the percentage of time >140 mg/dL between midnight to 6:00 am. The primary outcome was the rate of large for gestational age, defined as >90^th percentile on the Duryea et al. nomogram. TAR was expressed as a percentage of all CGM readings, mean glucose and standard deviation (SD) were analyzed. Spearman’s rank correlation coefficient test was used to examine nocturnal TAR and neonatal birthweight; p value of < 0.05 was considered as a statistically significant value.

Results: Of the 92 recruited participants, 6 (6.5%) had a LGA neonate. Individuals with LGA did not have a significantly increased nocturnal TAR as compared to those without LGA (p= 0.24). A correlation between increasing nocturnal TAR and increasing birthweight was not significant (p=0.51).

Conclusion: An association between increased nocturnal TAR and neonatal birthweight was not found. Larger studies are needed to investigate the role of nocturnal hyperglycemia and other adverse outcomes, as well as other maternal outcomes related to neonatal birthweight.