Icon Legend

This session is not in your schedule.

This session is in your schedule. Click again to remove it.

Presentation Icons

Additional registration fee required

Faculty have requested this content not be shared on social media

CME Credit Offered

Poster Icons

Foundation Awardee

No Social Media

Back

Q&A

Ultrasound/Imaging

Poster Session 4

(1040) The relation between maternal spiral artery perfusion in early pregnancy and subsequent adverse pregnancy outcomes

Wednesday, February 14, 2024

1:00 PM – 2:30 PM

Location: Prince George's Exhibit Hall CDE, Lower Atrium Level

Primary & Presenting Author(s)

RH

Rebecca Horgan, MBBCH

MFM Fellow
Eastern Virginia Medical School
Norfolk, VA, United States

Coauthor(s)

Elena Sinkovskaya, RDMS,MD,PhD,RDCS

Professor of Obstetrics and Gynecology and Director of Ultrasound Research and Education
Eastern Virginia Medical School
Norfolk, Virginia, United States
EK

Erkan Kalafat, MD, MS

Koc University School of Medicine
Istanbul, Istanbul, Turkey
George R. Saade, MD (he/him/his)

Professor & Chair of Ob-Gyn
Eastern Virginia Medical School
Norfolk, VA, United States
Alfred Abuhamad, MD

President, Provost and Dean
Eastern Virginia Medical School
Norfolk, VA, United States

Objective: To evaluate the relation between maternal spiral artery perfusion in early pregnancy and subsequent adverse pregnancy outcomes.

Study Design: Patients with non-anomalous pregnancies at < 13+6 weeks gestation without umbilical cord or placental abnormalities were enrolled in a longitudinal cohort study to evaluate the relation between placental novel sonographic markers and pregnancy outcomes. Ultrasounds were performed and data were ascertained by certified and trained sonographers and research coordinators. Superb Microvascular Imaging (SMI®) ultrasound technology was used to obtain spiral artery pulsatility index (SA-PI) and peak systolic velocity (SA-PSV) on first trimester ultrasound. Data was compared between patients who developed subsequent adverse pregnancy complications including preterm prelabor rupture of membranes (PPROM), fetal growth restriction (FGR) or preeclampsia (cases) and normal low risk patients (controls aged 18-35 years, with a body mass index (BMI) < 30, without existing comorbidities, who conceived spontaneously and had an uncomplicated pregnancy, with delivery >37 weeks’ gestation). Multinominal logistic regression tests were used for statistical analysis, with p < 0.05 used to denote statistical significance (R for Statistical Computing v.4.2.0).

Results: Amongst the 610 included pregnancies, 125 patients (20.5%) developed one of our adverse pregnancy outcomes: PPROM (n=30), preeclampsia (n=60) and FGR (n=45).There was no difference in mean central spiral artery PI in the first trimester amongst patients who developed PPROM 0.46 (p=0.29), FGR 0.57 (p=0.10) or preeclampsia 0.58 (p=0.24) compared to the controls. There was no difference in mean central spiral artery PSV in the first trimester amongst patients who developed PPROM 52.0 cm/sec (p=0.78), FGR 61.0 cm/sec (p=0.71) or preeclampsia 61.4 cm/sec (p=0.63) compared to the controls.

Conclusion: Mean SA-PI and SA-PSV in the first trimester are not associated with subsequent PPROM, FGR or preeclampsia.