(1041) The relation between placental intervillous perfusion in early pregnancy and subsequent adverse pregnancy outcomes

To evaluate the relation between placental intervillous perfusion in early pregnancy and subsequent adverse pregnancy outcomes.

Study Design: Patients with non-anomalous pregnancies at < 13+6 weeks gestation without umbilical cord or placental abnormalities were enrolled in a longitudinal cohort study to evaluate the relation between placental novel sonographic markers and pregnancy outcomes. Ultrasounds were performed and data were ascertained by certified and trained sonographers and research coordinators. Superb Microvascular Imaging (SMI®) ultrasound technology was used to obtain intervillous arteriole pulsatility index (IA-PI) and peak systolic velocity (IA-PSV) on first trimester ultrasound. Data was compared between patients who developed subsequent adverse pregnancy complications including preterm prelabor rupture of membranes (PPROM), fetal growth restriction (FGR) or preeclampsia (cases) and normal low risk patients controls (aged 18-35 years, with a body mass index (BMI) < 30, without existing comorbidities, who conceived spontaneously and had an uncomplicated pregnancy, with delivery >37 weeks’ gestation). Multinominal logistic regression tests were used for statistical analysis, with p < 0.05 used to denote statistical significance (R for Statistical Computing v.4.2.0).

Results: Amongst the 610 included pregnancies, 125 patients (20.5%) developed one of our adverse pregnancy outcomes: PPROM (n=30), preeclampsia (n=60) and FGR (n=45). There was no difference in mean IA-PI in the first trimester amongst patients who developed PPROM 0.98 (p=0.60), FGR 1.13 (p=0.20) or preeclampsia 0.91 (p=0.15), compared with controls(n=90). There was no difference in mean IA-PSV in the first trimester amongst patients who developed PPROM 5.75 cm/sec (p=0.77), FGR 5.92 cm/sec (p=0.79) or preeclampsia 5.25 cm/sec (p=0.26) compared with controls (n=90).

Conclusion: Mean IA-PI and IA-PSV in the first trimester are not associated with subsequent PPROM, FGR or preeclampsia.