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Epidemiology

Poster Session 4

(1050) Stillbirth as a risk factor for dementia: a prospective population-based UK Biobank study

Wednesday, February 14, 2024
1:00 PM – 2:30 PM  
Location: Prince George's Exhibit Hall CDE, Lower Atrium Level
Objective:

Adverse pregnancy outcomes (APO) have been reported to increase the risk of long-term cardiovascular or metabolic disease later in life. In the current study, we tried to evaluate the risk of dementia in middle-aged women according to the history of APO.

Study Design:

The UK Biobank is a prospective cohort study from 2006 to 2010, encompassing > 500,000 individuals at 40-60 years from the United Kingdom. Among them, we included 220,395 women and compared the new onset of dementia according to the history of APO using the Cox proportional hazard model.

Results:

In middle-aged women, dementia has newly occurred in a total of 3,047 women (1.38%) during follow up. Among APOs, only history of stillbirth increased the risk of  dementia whereas other APOs such as hypertensive disease in pregnancy, gestational diabetes mellitus, and recurrent spontaneous abortion was not associated with the risk of dementia. Even after adjusting the confounding variables, women who had a history of stillbirth increased risk of a new onset of dementia. (HR 1.1855, p=0.048)

Conclusion:

History of stillbirth was associated with an increased risk of dementia and should be also considered as a risk factor for dementia.