(1120) The Impact of Age on Adverse Obstetrical Outcomes among Pregnant Women with COVID-19 Infection.

Pregnant individuals experienced a more severe course of COVID-19 infection. Advanced age is widely recognized as a risk factor for severe disease and its complications, as well as for adverse obstetrical complications.
Therefore, our study aimed to investigate the association between maternal age at the time of COVID-19 infection and obstetrical adverse outcomes.

Study Design:

We conducted a retrospective cohort study at a tertiary single medical center, which included all singleton gestations of women with COVID-19 infection within a week prior to or after delivery, who delivered between 2020 and 2022. Exclusion criteria included women with incomplete medical records, multiple gestations and nulliparity. The women were categorized into two groups: below and above 35 years old. A multivariable logistic regression model was used to adjust for confounders such as obesity, cesarean delivery, induction of labor, epidural analgesia and birthweight.

Results: Our study included 443 patients with peripartum COVID-19 infection, of whom 354 were younger than 35 years and 89 were 35 years or older. We observed an increased risk of cesarean delivery (Table 1: 28.1% Versus 16.1%, P value= 0.01) and an increased risk of preterm delivery before 34 weeks (8% Versus 1.7%, P Value= 0.006) among the older age group.
Using multivariate logistic regression model after adjusting for maternal obesity, induction of labor, epidural analgesia and neonatal birthweight, the association between preterm delivery before 34 weeks and advanced maternal age remained significant (Adjusted Odd Ratio 8.04, P value=0.021).

Conclusion: Maternal age over 35 years is a risk factor for preterm delivery before 34 weeks in pregnant women with peripartum COVID-19 infection.