Skip to main content
SMFM 2024 Pregnancy Meeting Main banner
Final Program


Icon Legend
This session is not in your schedule.
This session is in your schedule. Click again to remove it.
Presentation Icons
Additional registration fee required
Additional registration fee required
Faculty have requested this content not be shared on social media
Faculty have requested this content not be shared on social media
CME Credit Offered
CME Credit Offered
Poster Icons
Foundation Awardee
Foundation Awardee
No Social Media
No Social Media
Back
Q&A

Basic Science

Poster Session 2

(488) Development of umbilical vessels as vascular grafts

Tuesday, February 13, 2024
3:30 PM – 5:00 PM  
Location: Prince George's Exhibit Hall CDE, Lower Atrium Level

    Primary & Presenting Author(s)

  • Young Mi Jung, MD (she/her/hers)

    Korea University College of Medicine, Seoul, Republic of Korea
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

    • Coauthor(s)

  • YS

    Ye Seon Seok, BS

    Korea University College of Medicine, Seoul, Republic of Korea
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • SL

    So Young Lee, BS

    Korea University College of Medicine, Seoul, Republic of Korea
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • SH

    Su Jung Hong, MD

    Korea University College of Medicine, Seoul, Republic of Korea
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • MO

    Min-Jeong Oh, MD, PhD

    Korea University College of Medicine, Seoul, Republic of Korea
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

Objective: Small-diameter arterial cardiovascular disease often requires the replacement of damaged or disease blood vessels with autologous graft such as saphenous vein or thoracic artery or synthetic graft. However, the supply of suitable vessels is often limited, and there are potential limitations such as thrombogenic risk and lack of integration associated with natural grafts. To overcome these challenges, researchers have explored decellularized tissue engineering as a promising alternative. This study aimed to create a decellularized umbilical vessel and evaluate its potential as a small-diameter vascular graft.

Study Design: We created decellularized blood vessels using umbilical cords obtained from full-term deliveries. After separating them into artery and vein, the vessels underwent freezing, thawing, and chemical treatments to remove cellular components. Confirmation of successful decellularization was achieved through H&E staining. Subsequently, we performed interposition of these decellularized vessels into the abdominal aorta of rabbits with a similar diameter.

Results: After one week following the transposition into the rabbit's abdominal aorta, we observed that the decellularized vessels maintained their structural integrity and demonstrated appropriate patency. Upon conducting a postmortem examination of the rabbit, even then, we confirmed the absence of thrombus formation, indicating that blood clots did not occur.

Conclusion: This study confirmed the potential of umbilical cord blood vessels as a novel artificial blood vessel. However, further research is required for practical implementation.