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Operative Obstetrics

Poster Session 3

(660) Offspring Long-Term Infectious Morbidity following Pregnancies with Cervical Cerclage

Wednesday, February 14, 2024

8:30 AM – 10:00 AM

Location: Prince George's Exhibit Hall CDE, Lower Atrium Level

Primary & Presenting Author(s)

Amir Snir, MD

Soroka University Medical Center
Beer-Sheva, HaDarom, Israel, Israel

Coauthor(s)

PS

Polina Schwarzman, MD

Soroka
Beer-Sheva, HaDarom, Israel
Tamar Wainstock, PhD (she/her/hers)

Ben Gurion University
Beer-Sheva, HaDarom, Israel
Eyal Sheiner, MD, PhD

Head of department of Obstetrics and Gynecology B, Soroka University Medical Center
Soroka University Medical Center
Beer-Sheva, HaDarom, Israel

Objective: Cervical cerclage is an acceptable procedure in women with cervical insufficiency and known as effective in prevention of preterm delivery. Since the presence of foreign body during pregnancy may change the vaginal microbiom, we aimed to study whether a cervical cerclage is associated with long-term infectious morbidity of the offspring.

Study Design:

A population-based cohort study was performed at a tertiary medical center, including all singleton deliveries between the years 1991-2023. Long-term infectious morbidity was compared among offspring after pregnancies with and without cervical. A Cox proportional hazards model was used to control for confounders.

Results: Out of 354,940 offspring included in the analysis, 0.4% (n=1416) were following pregnancies with cervical cerclage. Total infectious morbidity was comparable between the two study groups (OR 1.0, 95% CI 0.9 – 1.1; p = 0.369, Table). However, while controlling for confounders such as gestational age and mode of delivery, a significant association between cervical cerclage placement during pregnancy and long term offspring’s infectious morbidities risk reduction was demonstrated (adjusted HR 0.9, 95%CI 0.87 – 0.99, p = 0.036).

Conclusion: Cervical cerclage placement during pregnancy might have a protective effect for long-term infectious morbidity of the offspring. Further investigation regarding the influence of cervical cerclage on vaginal microbiome may be valuable.