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Q&A

Public Health/Global Health

Poster Session 1

(294) Differences in demographic and obstetrical characteristics among pregnant women with and without COVID-19 vaccination

Tuesday, February 13, 2024

10:30 AM – 12:00 PM

Location: Prince George's Exhibit Hall CDE, Lower Atrium Level

Primary Author(s)

Alla Saban, MD, MPH

Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Beer Sheva, HaDarom, Israel, Israel

Presenting Author(s)

Yael Reicher, MD (she/her/hers)

Soroka University Medical Center
Givat shmuel, HaMerkaz, Israel

Coauthor(s)

Noa Leybovitz-Haleluya, MD (she/her/hers)

OB/Gyn resident
Soroka University Medical Center
Meitar, HaDarom, Israel
Lior Yahav, MD, MPH

Soroka Medical Center
Beer-Sheva, HaDarom, Israel
AW

Adi Y. Weintraub, MD

Soroka Medical Center
Beer-Sheva, HaDarom, Israel
RH

Reli Hershkovitz, MD

Head of the Obstretics and Gynecology Division
Soroka Medical Center
Omer, HaDarom, Israel
Tamar Eshkoli, MD

Senior
Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Beer Sheva, HaDarom, Israel, Israel

Objective:

Coronavirus disease 2019 (COVID-19) infection posed elevated risks of severe illness and adverse obstetrical outcomes for pregnant women. Limited data is available regarding women who have been vaccinated but remained uninfected. Therefore, our study aimed to compare demographic and clinical characteristics of vaccinated and unvaccinated pregnant women without COVID19 infection during the peripartum period.

Study Design:

We conducted a population-based study at a tertiary medical center, enrolling all women with singleton pregnancies who delivered between 2020 and 2022 and were uninfected with COVID-19. Exclusion criteria included women with incomplete medical records, multiple gestations, and fetal malformations. The study group consisted of women who had received the COVID-19 vaccine, the comparison group consisted of women who had not been vaccinated. We studied the differences in demographic and obstetrical characteristics between both groups. Women with peripartum infection with COVID-19 were excluded.

Results: The study included a total of 26,250 women who met the inclusion criteria. Among them, 3,379 received COVID-19 vaccination. Among vaccinated women, there was significantly higher rate

of women with Jewish ethnicity and women above the age of 35. In addition,

women with COVID-19 vaccination were found to be significantly associated with an increased risk of cesarean delivery, gestational diabetes, oligohydramnios, induction of labor and epidural anesthesia. However, after conducting a multivariable logistic regression analysis and controlling for confounders the association remained significant only between COVID -19 vaccination and the use of epidural anesthesia (adjusted OR 1.46, 95% CI 1.31-1.63; p< 0.001).

Conclusion:

In the vaccinated group, there was a significantly greater proportion of women aged 35 and above, as well as those of Jewish ethnicity. Additionally, pregnant women who received the COVID-19 vaccination demonstrated a notable increase in the use of epidural anesthesia.